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KMID : 0615720140310020075
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 2 p.75 ~ p.85
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Inhibitory Effect of Bee Venom Toxin on the Growth of Cervix Cancer C33A Cells via Death Receptor Expression and Apoptosis
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Ko Seong-Cheol
Song Ho-Sueb
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Abstract
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Objectives: We investigated whether bee venom(BV) inhibit cell growth through enhancement of death receptor expressions in the human cervix cancer C33A cells.
Methods: BV(1∼5 μg/ml) inhibited the growth of cervix cancer C33A cells by the induction of apoptotic cell death in a dose dependent manner.
Results: Consistent with apoptotic cell death, expression of Fas, death receptor(DR) 3, 4, 5 and 6 was increased concentration dependently in the cells. Moreover, Fas, DR3 and DR6 revealed more sensitivity to BV. Thus, We reconfirmed whether they actually play a critical role in anti-proliferation of cervix cancer C33A cells. Consecutively, expression of DR downstream pro-apoptotic proteins including caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-κB were also inhibited by treatment with BV in C33A cells.
Conclusions: These results suggest that BV could exert anti-tumor effect through induction of apoptotic cell death in human cervix cancer C33A cells via enhancement of death receptor expression, and that BV could be a promising agent for preventing and treating cervix cancer.
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KEYWORD
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Bee venom, Cervix cancer, C33A, Death receptor, Apoptosis
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